Bioprocessing
Ward, Owen P.,
Bioprocessing - Buckingham : Open University Press, Imprint : Springer, 1991. - x, 198 p. : ill. ; - Open University Press biotechnology series .
Includes index
Machine generated contents note: CHAPTER 1 Introduction: Biomaterials and -- Bioprocessing 1 -- 1.1 Raw materials 2 -- 1.2 Cell cultivation 5 -- 1.3 Enzymes 9 -- 1.4 Product purification 10 -- 1.5 Further reading 14 -- CHAPTER 2 Bulk Bioprocessing Operations 15 -- 2.1 Agitation and mixing 15 -- 2.2 Heat transfer 20 -- 2.3 Size reduction and enlargement 25 -- 2.4 Solid-liquid separations 30 -- 2.5 Solid-solid separations 35 -- 2.6 Further reading 35 -- CHAPTER 3 Bioreactors in Bioprocessing 37 -- 3.1 Microbial bioreactors 37 -- 3.2 Non-microbial cell culture systems 43 -- 3.3 Bioreactor sterilization and sterility -- maintenance 47 -- 3.4 Bioreactor control 48 -- 3.5 Enzyme bioreactors 49 -- 3.6 Further reading 53 -- CHAPTER 4 Biochemical Separations 55 -- 4.1 Precipitation 55 -- 4.2 Crystallization 57 -- 4.3 Membrane processes 57 -- 4.4 Chromatographic methods in -- bioprocessing 60 -- 4.5 Liquid-liquid extraction 64 -- 4.6 Supercritical fluid extraction 67 -- 4.7 Process scale continuous electrophoresis 67 -- 4.8 Lyophilization 69 -- 4.9 Further reading 71 -- CHAPTER 5 Sterilization and Preservation in -- Bioprocessing 73 -- 5.1 Dry-heat sterilization 73 -- 5.2 Steam sterilization 74 -- 5.3 Gas sterilization 76 -- 5.4 Ionising radiation 76 -- 5.5 Other sterilants 76 -- 5.6 Filtration 76 -- 5.7 Food preservatives and stabilizers 77 -- 5.8 Stabilizers of other biological solutions 79 -- 5.9 Further reading 80 -- CHAPTER 6 Bulk Processing of Animal and Plant -- Materials 81 -- 6.1 Cereal processing 82 -- 6.2 Baking 87 -- 6.3 Fruits and vegetables 88 -- 6.4 Coffee and tea 91 -- 6.5 Chocolate and cocoa products 92 -- 6.6 Sugar production 94 -- 6.7 Milk processing 96 -- 6.8 Meat processing 101 -- 6.9 Egg processing 102 -- 6.10 Animal blood processing 103 -- 6.11 Fats and oils - manufacture and -- processing 105 -- 6.12 Further reading 108 -- CHAPTER 7 Purification of Fine Chemicals from -- Non-microbial Sources 110 -- 7.1 Extraction of plant products 110 -- 7.2 Fish by-products 113 -- 7.3 Animal by-products 113 -- 7.4 Human products 115 -- 7.5 Further reading 120 -- CHAPTER 8 Fermentation and Cell Culture -- Processes 121 -- 8.1 Examples of microbial fermentation -- processes 122 -- 8.2 Animal cell culture 130 -- 8.3 Plant cell culture 134 -- 8.4 Further reading 135 -- CHAPTER 9 Recovery of Cell Products 137 -- 9.1 Downstream processing steps 139 -- 9.2 Examples of recovery processes 140 -- 9.3 Further reading 149 -- CHAPTER 10 Enzyme Bioprocessing Applications 151 -- 10.1 Bulk industrial enzymes 151 -- 10.2 Biotransformations 159 -- 10.3 Concluding remarks 166 -- 10.4 Further reading 168 -- CHAPTER 11 Waste Treatment 170 -- 11.1 Waste water treatment 170 -- 11.2 Trickling filters 174 -- 11.3 Rotating biological contactors 174 -- 11.4 Activated sludge 174 -- 11.5 Sludge processing 175 -- 11.6 Composting 175 -- 11.7 Micro-organisms and enzymes as waste -- treatment processing aids 175 -- 11.8 Further reading 177 -- CHAPTER 12 Good Manufacturing 178 -- 12.1 Further reading 181.
Methods for processing of biological materials into useful products represent essential core manufacturing activities of the food, chemical and pharmaceutical industries. On the one hand the techniques involved include well established process engineering methodologies such as mixing, heat transfer, size modification and a variety of separatIon and fermentation procedures. In addition, new bioprocessing practices arising from the exciting recent advances in biotech nology, including innovative fermentation cell culture and enzyme based operations, are rapidly extending the frontiers of bioprocessing. These develop ments are resulting in the introduction to the market place of an awesome range of novel biological products having unique applications. Indeed, the United States Office of Technology Assessment· has concluded that 'competitive advantage in areas related to biotechnology may depend as much on developments in bioprocess engineering as on innovations in genetics, immunology and other areas of basic science'. Advances in analytical instrumentation, computerization and process automation are playing an important role in process control and optimization and in the maintenance of product quality and consistency characteristics. Bioprocessing represents the industrial practice of biotechnology and is multidisciplinary in nature, integrating the biological, chemical and engineering sciences. This book discusses the individual unit operations involved and describes a wide variety of important industrial bioprocesses. I am very grateful to Sanjay Thakur who assisted me in the collection of material for this book.
9781461539148 1461539145 9781461367451
Biochemical engineering.
Biotechnologie
660.6 / WAR
Bioprocessing - Buckingham : Open University Press, Imprint : Springer, 1991. - x, 198 p. : ill. ; - Open University Press biotechnology series .
Includes index
Machine generated contents note: CHAPTER 1 Introduction: Biomaterials and -- Bioprocessing 1 -- 1.1 Raw materials 2 -- 1.2 Cell cultivation 5 -- 1.3 Enzymes 9 -- 1.4 Product purification 10 -- 1.5 Further reading 14 -- CHAPTER 2 Bulk Bioprocessing Operations 15 -- 2.1 Agitation and mixing 15 -- 2.2 Heat transfer 20 -- 2.3 Size reduction and enlargement 25 -- 2.4 Solid-liquid separations 30 -- 2.5 Solid-solid separations 35 -- 2.6 Further reading 35 -- CHAPTER 3 Bioreactors in Bioprocessing 37 -- 3.1 Microbial bioreactors 37 -- 3.2 Non-microbial cell culture systems 43 -- 3.3 Bioreactor sterilization and sterility -- maintenance 47 -- 3.4 Bioreactor control 48 -- 3.5 Enzyme bioreactors 49 -- 3.6 Further reading 53 -- CHAPTER 4 Biochemical Separations 55 -- 4.1 Precipitation 55 -- 4.2 Crystallization 57 -- 4.3 Membrane processes 57 -- 4.4 Chromatographic methods in -- bioprocessing 60 -- 4.5 Liquid-liquid extraction 64 -- 4.6 Supercritical fluid extraction 67 -- 4.7 Process scale continuous electrophoresis 67 -- 4.8 Lyophilization 69 -- 4.9 Further reading 71 -- CHAPTER 5 Sterilization and Preservation in -- Bioprocessing 73 -- 5.1 Dry-heat sterilization 73 -- 5.2 Steam sterilization 74 -- 5.3 Gas sterilization 76 -- 5.4 Ionising radiation 76 -- 5.5 Other sterilants 76 -- 5.6 Filtration 76 -- 5.7 Food preservatives and stabilizers 77 -- 5.8 Stabilizers of other biological solutions 79 -- 5.9 Further reading 80 -- CHAPTER 6 Bulk Processing of Animal and Plant -- Materials 81 -- 6.1 Cereal processing 82 -- 6.2 Baking 87 -- 6.3 Fruits and vegetables 88 -- 6.4 Coffee and tea 91 -- 6.5 Chocolate and cocoa products 92 -- 6.6 Sugar production 94 -- 6.7 Milk processing 96 -- 6.8 Meat processing 101 -- 6.9 Egg processing 102 -- 6.10 Animal blood processing 103 -- 6.11 Fats and oils - manufacture and -- processing 105 -- 6.12 Further reading 108 -- CHAPTER 7 Purification of Fine Chemicals from -- Non-microbial Sources 110 -- 7.1 Extraction of plant products 110 -- 7.2 Fish by-products 113 -- 7.3 Animal by-products 113 -- 7.4 Human products 115 -- 7.5 Further reading 120 -- CHAPTER 8 Fermentation and Cell Culture -- Processes 121 -- 8.1 Examples of microbial fermentation -- processes 122 -- 8.2 Animal cell culture 130 -- 8.3 Plant cell culture 134 -- 8.4 Further reading 135 -- CHAPTER 9 Recovery of Cell Products 137 -- 9.1 Downstream processing steps 139 -- 9.2 Examples of recovery processes 140 -- 9.3 Further reading 149 -- CHAPTER 10 Enzyme Bioprocessing Applications 151 -- 10.1 Bulk industrial enzymes 151 -- 10.2 Biotransformations 159 -- 10.3 Concluding remarks 166 -- 10.4 Further reading 168 -- CHAPTER 11 Waste Treatment 170 -- 11.1 Waste water treatment 170 -- 11.2 Trickling filters 174 -- 11.3 Rotating biological contactors 174 -- 11.4 Activated sludge 174 -- 11.5 Sludge processing 175 -- 11.6 Composting 175 -- 11.7 Micro-organisms and enzymes as waste -- treatment processing aids 175 -- 11.8 Further reading 177 -- CHAPTER 12 Good Manufacturing 178 -- 12.1 Further reading 181.
Methods for processing of biological materials into useful products represent essential core manufacturing activities of the food, chemical and pharmaceutical industries. On the one hand the techniques involved include well established process engineering methodologies such as mixing, heat transfer, size modification and a variety of separatIon and fermentation procedures. In addition, new bioprocessing practices arising from the exciting recent advances in biotech nology, including innovative fermentation cell culture and enzyme based operations, are rapidly extending the frontiers of bioprocessing. These develop ments are resulting in the introduction to the market place of an awesome range of novel biological products having unique applications. Indeed, the United States Office of Technology Assessment· has concluded that 'competitive advantage in areas related to biotechnology may depend as much on developments in bioprocess engineering as on innovations in genetics, immunology and other areas of basic science'. Advances in analytical instrumentation, computerization and process automation are playing an important role in process control and optimization and in the maintenance of product quality and consistency characteristics. Bioprocessing represents the industrial practice of biotechnology and is multidisciplinary in nature, integrating the biological, chemical and engineering sciences. This book discusses the individual unit operations involved and describes a wide variety of important industrial bioprocesses. I am very grateful to Sanjay Thakur who assisted me in the collection of material for this book.
9781461539148 1461539145 9781461367451
Biochemical engineering.
Biotechnologie
660.6 / WAR