TY - BOOK AU - Primrose,S.B. TI - Principles of genome analysis SN - 9780632049837 U1 - 574.873282 PY - 1998/// CY - Oxford, Malden, MA PB - Blackwell Science KW - Gene mapping KW - Nucleotide sequence KW - Chromosome Mapping KW - Base Sequence N1 - Included index; 1. Rationale for mapping and sequencing genomes -- 2. The organization and structure of genomes -- 3. Subdividing the genome -- 4. Assembling a physical map of the genome -- 5. Sequencing methods and strategies -- 6. Analysing sequence data -- 7. Finding genes in large genomes N2 - Genome analysis and genomics are at the forefront of current research in the life sciences. Since the first edition of Principles of Genome Analysis was published, the sequencing of genomes has continued apace, with the major landmark of the human genome sequence being achieved in 2001. Now the emphasis of biological research is on genomics: the understanding of gene function and the interaction of gene products at the whole genome level. As before, this book provides a step-by-step outline of the techniques involved in genome mapping and sequencing. Additionally, the text has been greatly expanded to cover sub-disciplines of genomics, revisions of sections on genome sequencing and bioinformatics, and new chapters on comparative genomics, functional genomics and proteomics. The book concludes with an exciting new chapter describing a variety of ways to utilize genome analysis and sequencing in biology, medicine and agriculture. Aimed at advanced undergraduates, this text will follow the same format as the highly successful Principles of Gene Manipulation by Primrose, Twyman and Old, now in its sixth edition ER -